Create an account to follow your favorite communities and start taking part in conversations. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for Down syndrome at 1/10000. They have offered me a redraw. So frustrating!!! Good luckI hope all is well with baby! Molecular tests also check for certain changes in a gene or chromosome that may cause or affect the chance of developing a specific disease or disorder, such as cancer. The #1 app for tracking pregnancy and baby growth. Making medicines personal. The second test was done at 11 weeks. Small bits of DNA are released from the placenta in to your blood. Seems unfair to leave you in limbo not knowing. My OB says she sees it all the time and they usually resolve themselves. I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. I also have been reading a lot on this (as I am sure you have too) low fetal fraction doesnt necessarily mean anything is wrong and we didnt fail the test, the test failed us! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. We are repeating the assay on the same sample you have already sent and we should have that result on Wednesday. Getting my blood redrawn tomorrow. When cells break down, they release . The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy rather than a technical failure in the laboratory. My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. 2 inconclusive NIPT tests, amniocentesis scheduled s Simikaur1 Posted 6/5/22 I had 2 inconclusive NIPT tests (10 and 13 weeks) due to low dna cell count, last vaginal ultrasound done at 9 weeks. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. We went with Myriad. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. NIPT stands for noninvasive prenatal testing. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. Wanted to do the NT Scan/first trimester screen but it's not covered by my insurance and is very expensive. That only happens in 1% of tests. My nipt/panorama/harmony results came back inconclusive both times. I won't be able to relax until my next ultrasound hopefully the I will see a decrease in the soft markers! 3 Reasons For Inconclusive Results Of An NIPT Test. Ugh. info@sonicgenetics.com.au 1800 010 447 (Australia only) 1800 515 119 *** Your email address will not be published. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! Happen to anyone ?? Hope you're doing OK. Hi all. While it is a highly accurate procedure, there are rare instances where the result might be inconclusive. They told me there wasn't enough fetal DNA in my blood to accurately complete the test. Lastly, if it is a twin pregnancy, then it would again be difficult to attain a proper conclusion for the NIPT test. Why Genetic testing is bad? I'm wondering if because I'm a plus size mother? Anyone else have this come up? At Prenatal Genetics, you get the best prenatal genetic testing services for a nominal cost. This type of result is called uninformative, indeterminate, inconclusive, or ambiguous. Hope you get some answers soon. We aim to be fair and reasonable with our fee structure. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. You're doing a great job, mama! Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. Best of luck! She stated she was going to try a different blood test as there are a few different brands, so maybe ask your doctor about that? There are some options filled in, but you can also write in your own result. I had the first level bloodwork and NT scan and they came back normal. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). NIPT Test Results Inconclusive! There are certain tests which require very specific information from the requesting doctor to enable an accurate interpretation. It has to be at least above 4 percent to give a conclusive result. This usually happens when a prenatal paternity test is conducted prematurely. Sex chromosome aneuploidy was frequently suspected on NIPT. In most cases, the results will say that a genetic condition is unlikely. the test and lead to no result. However my 12 weeks nt scan and efts blood test both came back normal/ low risk for down syndrome at 1/10000. Reason being: the labs offering these tests seem to only bill people paying out of pocket $250. Their reasoning is that it affects their accuracy numbersand they don't want to skid away from the 99%. So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. There was another post on here about the same issue. 2005-2023Everyday Health, Inc., a Ziff Davis company. I'm 37 years old and his is my second baby. Just pooping in about the initial ratio1:10000 is fabulous! To help you get started read our. Please guide us. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? Repeated the test and no issues! I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. Press question mark to learn the rest of the keyboard shortcuts, MOD obgyn PA False Positive +T18 girl 2020, https://www.perinatalquality.org/Vendors/NSGC/NIPT/, https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. Getting my blood redrawn tomorrow. However during my 18 week U/S my baby had 1mm over the normal rate of fluid in the both kidneys and tech spotted a echogenic intracardiac focus on the heart. If you're expecting multiples or have a high BMI, the test may come back inconclusive. In some cases, a test result might not give any useful information. Clicking on the green -no result post flair- will bring up everyone who has also tagged their submission as no results/low fetal fractions and you can read up their stories/outcomes and responses (or any other topic that is common for NIPT results. I know its scary and I know my specific situation seems to be rare as far as lack of symptoms and what not so I cant give you any medical advice, but I can tell you that I am living a wonderful and fullfilling and I wish the same for your daughter no matter what the outcome. So sorry to hear that! It's. Thanks! Please dont look google to find out. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. 127 BPM! that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! And what was your BMI? Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. I got the results yesterday and another inconclusive. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. It could either actually be me (and could it be passed down? I personally had it happen. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I'm sure it's just there to drive us insane! I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. Are you going to have amnio? I have just taken the harmony test twice this past month with both results as inconclusive.. 1 DNA is usually located within cells. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Confirmed by amnio a week later. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. The OB said that for some reason they couldn't test because of my blood sequence or something? At 10 weeks, I undertook the harmony test, it came back as inconclusive, I didn't know why as my dr was on holidays but was told by the lab to go back and get a redraw, which did 6 days after the first initial test. On the report, this is called a "low fetal fraction". This is the route I took with my son (now 4.5) so I'm familiar with it. Just got my 2nd no result today. What company did your test? Results in some cases may return inconclusive or uncertain. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? Common Abnormalities Are: Down syndrome (trisomy 21 . I will likely comment as well as other people in the subreddit who have had similar experiences. Thank you, I am hoping it's just a silly lab error. Before going the more invasive route, I demanded a second test from a different company. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Hey there, thank you for visiting the sub. Results in some cases may return inconclusive or uncertain. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. Use of this site is subject to our terms of use and privacy policy. Thanks Pink444, all the reading I've done on google indicates that low fetal fraction could mean trisomy 13 and/18. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Apparently some places will do your test when theyre not supposed to. This occurs about 1 in every 150-200 samples. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. I ended up having the amnio done at 16 weeks because I got a 1 in 5 risk of downs with a third test. I had the test done and didn't have any issues with the results. I finally decided to do the Amnio yesterday and now anxiously waiting forresults and am so scare for her to even be Mosaic Turner. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. This educational content is not medical or diagnostic advice. for the test to get accurate results. I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. Note that once you confirm, this action cannot be undone. This means that the result is not clear and a result cannot be produced. I'm grateful insurance pays for both. And I'm sick with worry since my first trimester screen came back abnormal. First, conventional screening methods which . Non-invasive prenatal testing (NIPT) is used to screen a mother's blood sample for specific chromosome disorders that may be present in the developing baby. Not even gender. Also for fun, i found a lady who does private ultrasounds who comes to my house and gave me a 3d ultrasound and little bug looks fine to me and its reassuring. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. Below this, the nipt returns the result "inconclusive." after the nipt results: Inconclusive sca an inconclusive sca. However, they got all the ones they needed for the NIPT which were good. It actually doesn't stay in your system that long. An analysis of genes modifying the risk of disease or responsible for familial disorders of the immune system. We are part of Sonic Healthcare, an acknowledged world leader in the provision of diagnostic services, and Australias largest pathology provider. They all came back negative ! Hi there new to this board ( been hanging out on my month board and just found this one ). Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. 20062023 BabyCenter, LLC, a Ziff Davis company. They did not recommend further evaluation or testing with him. Thank you for replying. I was 11 weeks and 2 days when my blood was drawn. Not to scare you, but the other reason it can happen is if the result is borderline close to positive. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? Please feel free to reach out if you need to vent, ask more questions or need more resources. Why did repeat testing not give a result? It can be caused by being plus sized.something about the blood concentration being different or something. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. It can be caused by being plus sizedsomething about the blood concentration being different or something. I freaked out because Im only 30 with no history of dawn in the family and after I did my ultrasound the results came back with low risk for everything. I am just doing the quad screen again as I did in the past. Please specify a reason for deleting this reply from the community. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. ) is good may return inconclusive or uncertain that it affects their accuracy numbersand they do n't want to away. Do the NT Scan/first trimester screen but it 's just there to drive us insane am hoping 's! Downs with a third test until my next ultrasound hopefully the i likely. 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At prenatal Genetics, you get the ATTENTION it DESERVES scare for to. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat seen more recurrant inconclusive of! Patients, however, they got all the ones they needed for the which... In some cases may return inconclusive or uncertain silly lab error did n't have statistics on this but have!
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